PixelINR: Scan-Specific Self-Supervised MRI Reconstruction Based on Implicit Neural Representations

Songxiao Yang, Yafei Ou, and Masatoshi Okutomi
Department of Systems and Control Engineering, School of Engineering, Institute of Science Tokyo
Biomedical Signal Processing and Control, (February 2026) October 2025

Abstract

Accelerated MRI involves a trade-off between sampling sufficiency and acquisition time. Although supervised and self-supervised deep learning approaches have shown promise in reconstructing under-sampled MR images, they typically rely on large-scale training datasets. This dependence increases the risk of overfitting and hallucinated features, particularly when training data diverges from test-time distributions. In this paper, we propose PixelINR, a scan-specific, self-supervised reconstruction method based on implicit neural representations (INR) that requires only a single under-sampled scan for training. By eliminating the need for external training databases, scan-specific PixelINR mitigates hallucination risks and improves generalization to diverse acquisition settings. To further enhance image quality, we incorporate anti-blurriness regularization in the image domain and a frequency-domain inpainting loss, guiding the model to recover sharp structures and plausible k-space content. Experimental results demonstrate that PixelINR outperforms existing scan-specific approaches in both reconstruction accuracy and robustness.

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PixelINR: Scan-specific Self-supervised MRI Reconstruction Based on Implicit Neural Representations

Authors: Songxiao Yang, Yafei Ou, and Masatoshi Okutomi
Biomedical Signal Processing and Control, (February 2026) October 2025


@article{yang2026pixelinr,
  title={PixelINR: Scan-specific self-supervised MRI reconstruction based on implicit neural representations},
  author={Yang, Songxiao and Ou, Yafei and Okutomi, Masatoshi},
  journal={Biomedical Signal Processing and Control},
  volume={112},
  pages={108838},
  year={2026},
  publisher={Elsevier}
}